|Title||Association of Fitness With Incident Dyslipidemias Over 25 Years in the Coronary Artery Risk Development in Young Adults Study.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Sarzynski, MA, Schuna, Jr, JM, Carnethon, MR, Jacobs, DR, Lewis, CE, Quesenberry, CP, Sidney, S, Schreiner, PJ, Sternfeld, B|
|Journal||Am J Prev Med|
|Date Published||2015 Nov|
|Keywords||Adolescent, Adult, Cohort Studies, Dyslipidemias, Exercise Test, Female, Humans, Lipoproteins, LDL, Male, Middle Aged, Multivariate Analysis, Physical Fitness, Proportional Hazards Models, Risk Factors, United States, Young Adult|
INTRODUCTION: Few studies have examined the longitudinal associations of fitness or changes in fitness on the risk of developing dyslipidemias. This study examined the associations of (1) baseline fitness with 25-year dyslipidemia incidence and (2) 20-year fitness change on dyslipidemia development in middle age in the Coronary Artery Risk Development in Young Adults Study (CARDIA).
METHODS: Multivariable Cox proportional hazards regression models were used to test the association of baseline fitness (1985-1986) with dyslipidemia incidence over 25 years (2010-2011) in CARDIA (N=4,898). Modified Poisson regression models were used to examine the association of 20-year change in fitness with dyslipidemia incidence between Years 20 and 25 (n=2,487). Data were analyzed in June 2014 and February 2015.
RESULTS: In adjusted models, the risk of incident low high-density lipoprotein cholesterol (HDL-C); high triglycerides; and high low-density lipoprotein cholesterol (LDL-C) was significantly lower, by 9%, 16%, and 14%, respectively, for each 2.0-minute increase in baseline treadmill endurance. After additional adjustment for baseline trait level, the associations remained significant for incident high triglycerides and high LDL-C in the total population and for incident high triglycerides in both men and women. In race-stratified models, these associations appeared to be limited to whites. In adjusted models, change in fitness did not predict 5-year incidence of dyslipidemias, whereas baseline fitness significantly predicted 5-year incidence of high triglycerides.
CONCLUSIONS: Our findings demonstrate the importance of cardiorespiratory fitness in young adulthood as a risk factor for developing dyslipidemias, particularly high triglycerides, during the transition to middle age.
|Alternate Journal||Am J Prev Med|
|PubMed Central ID||PMC4615297|
|Grant List||HHSN268201300026C / HL / NHLBI NIH HHS / United States |
R01 HL078972 / HL / NHLBI NIH HHS / United States
AG 0005 / AG / NIA NIH HHS / United States
HHSN268201300025C / HL / NHLBI NIH HHS / United States
HHSN268201300027C / HL / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
HHSN268200900041C / HL / NHLBI NIH HHS / United States
HHSN268201300028C / HL / NHLBI NIH HHS / United States
R01 HL 078972 / HL / NHLBI NIH HHS / United States
HHSN268201300029C / HL / NHLBI NIH HHS / United States