TitleAssociation of cigarette smoking from adolescence to middle-age with later total and cardiovascular disease mortality: theHarvard Alumni Health Study.
Publication TypeJournal Article
Year of Publication2012
AuthorsWhitley, E, Lee, I-M, Sesso, HD, Batty, GD
JournalJ Am Coll Cardiol
Date Published10/2012
KeywordsAdolescent, Adult, Cardiovascular Diseases, Cohort Studies, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Proportional Hazards Models, Risk, Smoking, Time Factors, Universities

To the Editor:

Evidence regarding the future health impact of smoking at younger ages is usually based on retrospective reporting of this health behavior, which demonstrates only moderate agreement with contemporaneous reporting (1). Studies of subsequent mortality risk with prospectively measured smoking in adolescence or early adulthood are rare and tend to focus on total mortality (2, 3). Only one study (4) has considered cause-specific mortality, in particular cardiovascular disease (CVD). In addition, the single baseline measure of smoking in adolescence used in these studies is unlikely to completely capture lifetime risk For example, there is evidence that mortality risk in lifelong smokers versus lifelong nonsmokers is far greater than that estimated for current smokers versus nonsmokers at any individual time point (2).

Alternate JournalJ. Am. Coll. Cardiol.
PubMed ID23040571
PubMed Central IDPMC4170773
Grant List081021 / / Wellcome Trust / United Kingdom
R03 CA130068 / CA / NCI NIH HHS / United States
R21 DK081141 / DK / NIDDK NIH HHS / United States