TitleAnti-inflammatory activity of soy and tea in prostate cancer prevention.
Publication TypeJournal Article
Year of Publication2010
AuthorsHsu, A, Bray, TM, Ho, E
JournalExp Biol Med (Maywood)
Date Published06/2010
KeywordsAnti-Inflammatory Agents, Asia, Humans, Male, Prostatic Neoplasms, Prostatitis, Soy Foods, Tea, United States

Prostate cancer is the leading cancer-related cause of death for men in the USA. Prostate cancer risk is significantly lower in Asian countries compared with the USA, which has prompted interest in the potential chemo-preventive action of soy and green tea that are more predominant in Asian diets. It has been proposed that chronic inflammation is a major risk factor of prostate cancer, acting as both an initiator and promoter. Specifically, the nuclear factor-kappa B (NF-kappaB) pathway has been implicated as an important mediator between chronic inflammation, cell proliferation and prostate cancer. Dietary factors that inhibit inflammation and NF-kappaB may serve as effective chemo-preventive agents. Recent studies have demonstrated that soy and green tea have anti-inflammatory properties, and may have the potential to block the inflammatory response during cancer progression. This minireview discusses the relationship between chronic inflammation and prostate cancer, emphasizing on the significance of NF-kappaB, and further explores the anti-inflammatory effects of soy and green tea. Finally, we propose that dietary strategies that incorporate these bioactive food components as whole foods may be a more effective means to target pathways that contribute to prostate cancer development.

Alternate JournalExp Biol Med (Maywood)
PubMed ID20511670
PubMed Central IDPMC4125123
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
R01 CA107693 / CA / NCI NIH HHS / United States
CA107693 / CA / NCI NIH HHS / United States
NIEHS P30 ES00210 / ES / NIEHS NIH HHS / United States