TitleAdherence to healthy dietary guidelines and future depressive symptoms: evidence for sex differentials in the Whitehall II study.
Publication TypeJournal Article
Year of Publication2013
AuthorsAkbaraly, TN, Sabia, S, Shipley, MJ, Batty, GD, Kivimäki, M
JournalAm J Clin Nutr
Volume97
Issue2
Pagination419-27
Date Published2013 Feb
ISSN1938-3207
KeywordsAdult, Cohort Studies, Coronary Artery Disease, Depression, Diet, Female, Follow-Up Studies, Guidelines as Topic, Health Promotion, Humans, Male, Middle Aged, Nutrition Policy, Patient Compliance, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Secondary Prevention, Sex Factors, United Kingdom
Abstract

BACKGROUND: It has been suggested that dietary patterns are associated with future risk of depressive symptoms. However, there is a paucity of prospective data that have examined the temporality of this relation.

OBJECTIVE: We examined whether adherence to a healthy diet, as defined by using the Alternative Healthy Eating Index (AHEI), was prospectively associated with depressive symptoms assessed over a 5-y period.

DESIGN: Analyses were based on 4215 participants in the Whitehall II Study. AHEI scores were computed in 1991-1993 and 2003-2004. Recurrent depressive symptoms were defined as having a Center for Epidemiologic Studies Depression Scale score ≥16 or self-reported use of antidepressants in 2003-2004 and 2008-2009.

RESULTS: After adjustment for potential confounders, the AHEI score was inversely associated with recurrent depressive symptoms in a dose-response fashion in women (P-trend < 0.001; for 1 SD in AHEI score; OR: 0.59; 95% CI: 0.47, 0.75) but not in men. Women who maintained high AHEI scores or improved their scores during the 10-y measurement period had 65% (OR: 0.35%; 95% CI: 0.19%, 0.64%) and 68% (OR: 0.32%; 95% CI: 0.13%, 0.78%) lower odds of subsequent recurrent depressive symptoms than did women who maintained low AHEI scores. Among AHEI components, vegetable, fruit, trans fat, and the ratio of polyunsaturated fat to saturated fat components were associated with recurrent depressive symptoms in women.

CONCLUSION: In the current study, there was a suggestion that poor diet is a risk factor for future depression in women.

DOI10.3945/ajcn.112.041582
Alternate JournalAm. J. Clin. Nutr.
PubMed ID23283506
PubMed Central IDPMC3545684
Grant List / / British Heart Foundation / United Kingdom
RG/13/2/30098 / / British Heart Foundation / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
G8802774 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
HS06516 / HS / AHRQ HHS / United States
R01AG034454 / AG / NIA NIH HHS / United States
R01HL036310 / HL / NHLBI NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R01AG013196 / AG / NIA NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom