|Title||Abstract IA47: Resolving the complex problem of tobacco-caused lung cancer disparities in the U.S|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Fagan, P, Moolchan, ET, Pokhrel, P, Herzog, T, Cassel, K, Pagano, I, Franke, A, Kaholokula, JKeawe'aimo, Sy, A, Alexander, LA, Trinidad, DR, Sakuma, K-L, Johnson, CAnderson, Antonio, AM, Jorgensen, D, Lynch, T, Kawamoto, C, Clanton, MS|
|Journal||Cancer Epidemiology Biomarkers & Prevention|
|Pagination||IA47 - IA47|
Existing data show that lung cancer disparities are not explained by cigarette smoking dose and duration alone. Data from the Multiethnic Cohort Study show that Native Hawaiians and African Americans who smoked 10 cigarettes per day have an elevated risk of lung cancer compared to Japanese American, White, and Latino smokers. Prior studies also suggest that African Americans have slower nicotine metabolism compared to Whites. It remains unclear why we consistently observe slower rates of nicotine metabolism among African Americans, but higher rates of lung cancer since studies suggest that smokers with low levels of CPY2A6 activity may be less efficient in bioactivating tobacco smoke pre-carcinogens to carcinogens. Little is known about nicotine metabolism among Native Hawaiians and Filipinos who have disproportionate and unexplained lung cancer rates like African Americans.