Donald B. Jump, PhD

Professor
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Office: 541-737-4007

Milam Hall

Milam Hall 107A (Office)

2520 SW Campus Way

2520 SW Campus Way
Corvallis, OR 97331
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At OSU
Affiliation(s): 
School of Biological and Population Health Sciences
Nutrition
Center for Healthy Aging Research
Research/Career Interests: 

My colleagues and I, in the Molecular Nutrition and Diabetes Research lab, investigate the molecular and metabolic basis of complications associated with obesity and diabetes. Our current focus is on the role diet plays in the onset and progression of nonalcoholic fatty liver disease (NAFLD), a major global health problem.

The central theme of our research is that dietary fat plays a central role in the control of transcriptional regulatory networks regulating carbohydrate, lipid and protein metabolism. Consumption of high fat diets or diets with insufficient polyunsaturated fats (omega 6 and omega 3 fats) contribute to the complications associated with obesity and type 2 diabetes. Such changes in dietary fat content disrupts regulatory networks controlling cell function. These events lead to complications of diabetes, such as hyperglycemia, dyslipidemia, cardiovascular disease and fatty liver disease.

Our experimental approach employs a preclinical mouse model to assess the impact of specific dietary factors on the onset, progression and remission of NAFLD. Our goal is to develop a nutritional strategy to attenuate disease progression and promote disease remission.

The National Institutes of Health supports our research (DK112360).

A list of our publications can be found at the US National Library of Medicine (PUBMED): 

Beyond OSU
My Publications

2017

Journal Article

K. A. Lytle, Wong, C. P., and Jump, D. B., Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice, PLOS ONE, no. 4603715694913Suppl 12413624367446441413125105771810712858318382951Suppl 12224256130393, p. e0173376, 2017.

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