TitlePutative Links Between Sleep Apnea and Cancer: From Hypotheses to Evolving Evidence.
Publication TypeJournal Article
Year of Publication2015
AuthorsGozal, D, Farré, R, F. Nieto, J
JournalChest
Volume148
Issue5
Pagination1140-7
Date Published2015 Nov
ISSN1931-3543
KeywordsAnimals, Humans, Neoplasms, Sleep Apnea Syndromes
Abstract
 

In recent years, the potentially adverse role of sleep-disordered breathing in cancer incidence and outcomes has emerged. In parallel, animal models of intermittent hypoxia (IH) and sleep fragmentation (SF) emulating the two major components of OSA have lent support to the notion that OSA may enhance the proliferative and invasive properties of solid tumors. Based on several lines of evidence, we propose that OSA-induced increases in sympathetic outflow and alterations in immune function are critically involved in modifying oncologic processes including angiogenesis. In this context, we suggest that OSA, via IH (and potentially SF), promotes changes in several signaling pathways and transcription factors that coordinate malignant transformation and expansion, disrupts host immunologic surveillance, and consequently leads to increased probability of oncogenesis, accelerated tumor proliferation, and invasion, ultimately resulting in adverse outcomes.

DOI10.1378/chest.15-0634
Alternate JournalChest
PubMed ID26020135
PubMed Central IDPMC4631033
Grant ListR01 HL062252 / HL / NHLBI NIH HHS / United States
R01 HL065270 / HL / NHLBI NIH HHS / United States
HL-65270 / HL / NHLBI NIH HHS / United States
R01HL062252-11 / HL / NHLBI NIH HHS / United States